性别

男

通讯地址

遵义市新蒲新区学府西路6号

邮编

563000

邮箱

Guangchao_Xu@zmu.edu.cn

职称

副研究员

职务

无

简介

徐广超博士毕业于四川大学，2015-2017年通过国家公派于美国麻省大学医学院联合培养博士18个月。2019年7月进入遵义医科大学附属医院烧伤整形外科主要从事皮肤肿瘤发生和皮肤组织损伤修复的研究工作。已发表SCI论文25篇，IF>10共3篇，IF>5共12篇。相关论文以第一、共一和通讯作者已发表在Journal of Investigative Dermatology、Advanced Functional Materials、Oncogene、Nature communications和Molecular Therapy-Nucleic Acids等顶级期刊。目前主持国家自然科学基金青年项目和贵州省科技厅基础研究重点项目各一项，获得川渝科技学术大会优秀论文二等奖一项（排名第三）。

教育背景

2013年9月-2017年6月 四川大学生物治疗国家重点实验室 细胞生物学 博士,

2010年9月- 2013年6月 四川大学生物治疗国家重点实验室 细胞生物学 硕士

2006年9月- 2010年6月 安徽科技学院生命科学学院生物工程 学士

学术组织任职

中华医学会烧伤分会基础与转化学组委员

Frontiers in microbiology杂志客座编辑

主讲课程

无

科研项目

1.ITGA3介导靶向BRAF突变黑色素瘤MAPK和PI3K/mTOR双通路，国家自然科学基金青年项目(81902793) 2020.01-2022.12,20万元,在研,主持

2.LPCAT2/CPT1A介导脂滴形成和脂代谢激活促进黑色素瘤耐药3.发生的分子机制研究 贵州省科技厅基础研究重点项目(黔科合基础-ZK[2021]重点008) 2021.04-2025.04，30万元,在研,主持

3.不同浓度TNF-α对间充质干细胞外泌体microRNA及调控创面愈合的机制研究 贵州省科技厅科技支撑计划(黔科合支撑[2020]4Y148号),2020.01-2023.12,40万元,在研,参与,排名第二

发表论文

1.Zhen Wang, Fang Qi, Han Luo, Guangchao Xu*, Dali Wang*.Inflammatory microenvironment of skin wounds.Frontiers in immunology.2022 Mar 1;13:789274.(co-corresponding author)(IF =7.561)

2.Xiaobo Zheng^#, Jinen Song^#, Chune Yu^#, Zongguang Zhou^#, Xiaowei Liu, Jing Yu,Guangchao Xu, Jiqiao Yang, Xiujing He, Xin Bai, Ya Luo, Yu Bao, Huifang Li, Lie Yang, Mingqing Xu, Nan Song, Xiaodong Su, Jie Xu, Xuelei Ma*, Hubing Shi*. Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis.Signal Transduct Target Ther. 2022 Feb 28;7(1):60.（IF = 18.187）

3.Chune Yu^#, Dan Luo^#, Jing Yu^#, Min Zhang, Xiaobo Zheng,Guangchao Xu, Jiaxin Wang, Huiling Wang, Yufei Xu, Ke Jiang, Jie Xu, Xuelei Ma, Jing Jing^*, Hubing Shi^*.Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.Oncogene. 2022 Jan;41(2):191-203. (IF = 9.867)

4.Guangchao Xu^#, Ya Luo^#, Wenshuang Wu^#, Xiaowei Liu^#, Xin Yu, Yu Bao, Xiujing He, Jing Yu, Yanna Li, Jiqiao Yang, Rongjie Zhang, Chune Yu, Hongying Chen, Jie Xu, Jianping Hu, Jing Jing^*, Hubing Shi^*.The evolution of acquired resistance to BRAF inhibitor is sustained by IGF1-driven tumor vascular remodeling. Journal of Investigative Dermatology. 2022, 142(2): 445-458. (IF = 8.551)

5.Jianyi Li^#, Miaomiao Wei^#, Xin Liu, Shune Xiao, Yuan Cai, Fang Li, Jiao Tian, Fang Qi^*,Guangchao Xu^*,Chengliang Deng^*.The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds. Molecular Therapy-Nucleic Acids. 2021 Apr 1;24:554-578.(co-corresponding author) (IF = 8.886)

6.Wanru Qin^#,Guangchao Xu^#, Phillip W L Tai^#, Chunmei Wang^#, Li Luo, Chengjian Li, Xun Hu, Jianxin Xue, You Lu, Qiao Zhou, Qiang Wei, Tianfu Wen, Jiankun Hu, Yuanyuan Xiao, Li Yang, Weimin Li, Terence R Flotte^*, Yuquan Wei^*, Guangping Gao^*.Large-scale molecular epidemiological analysis of AAV in a cancer patient population. Oncogene. 2021 Apr;40(17):3060-3071.(co-first author) (IF = 9.867)

7.Xiaowei Liu^#, Yanlin Feng^#,Guangchao Xu^#, Yang Chen^#, Ya Luo, Jinen Song, Yu Bao, Chune Yu, Yanna Li, Haoyu Ye, Bowen Ke, Bo Chen, Jianping Hu, Jie, Xu, Huan Meng, Haiyuan Zhang^*, Hubing Shi^*.MAPK-Targeted Drug Delivered by a pH Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-cell Suppression. Advanced Functional Materials. 2019,29(1806916).(co-first author) (IF = 18.808)

8.Guangchao Xu^#, Peng Zhang^#, Fei Leng, Li Pan, ZhiYong Li, DanDan Yu, Yan Shan, QingZhong Yuan, Yuan Wen, Bo Mu, HuaShan Shi, Xiang Chen, ChunTing Wang^*.Inhibition of lymphatic metastases by a survivin dominant-negative mutant.Oncology Research. 2012;20(12):579-87. (IF = 5.574)

9.Chune Yu^#, Min Zhang^#, Jinen Song^#, Xiaobo Zheng^#,Guangchao Xu, Yu Bao, Jiang Lan, Dan Luo, Jianping Hu, Jingyi Jessica Li, Hubing Shi^*. Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy.Molecular Biomedicine. 2020,1(1):1-16.

10.Hung-Lun Hsu^#, Alexander Brown^#, Anna Loveland^#, Anoushka Lotun^#, Meiyu Xu, Li Luo,Guangchao Xu, Jia Li, Lingzhi Ren, Qin Su, Dominic Gessler, Yuquan Wei, Phillip Tai^*, Andrei Korostelev^*, Guangping Gao^*.Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties. Nature Communications. 2020 Jun 30;11(1):3279.(IF = 14.919)

11.Yuanyuan Xiao^#, Manish Muhuri^#, Shaoyong Li^#, Wanru Qin,Guangchao Xu, Li Luo, Jia L, Alexander J. Letizia, Sean K. Wang, Ying Kai Chan, Chunmei Wang, Sebastian P. Fuchs, Dan Wang, Qin Su, M. Abu Nahid, George M. Church, Michael Farzan, Li Yang, Yuquan Wei, Ronald C. Desrosiers, Christian Mueller^*, Phillip W.L. Tai^*, Guangping Gao^*.Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity. JCI Insight. 2019, 4(13): e99052.(IF = 8.315)

教材、专著编写

无

奖励

川渝科技学术大会优秀论文二等奖（排名第三）